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OJVRTM
Online
Journal of Veterinary Research©
Volume 17(10):571-577, 2013. Redacted 2017.
Acute
phase response in chickens challenged by wild Newcastle disease virus isolate
(JF820294.1.)
H. Habibi, H. Nili, K. Asasi, S. Nazifi*, N. Mosleh, S. Firouzi
Department of Clinical
Studies, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
ABSTRACT
H.
Habibi, H. Nili, K. Asasi, S. Nazifi*, N. Mosleh, S. Firouzi., Acute phase responses in village chickens
challenged by a wild Newcastle disease virus isolate (JF820294.1.), Onl J Vet Res., 17(10):571-577, 2013. Acute phase proteins (APP) are synthesized in
the liver during the acute phase response to trauma, infection, stress,
neoplasia, inflammation and Newcastle disease. Three groups of 15 Day old
chicks each were challenged with JF820294.1 virus,
vaccinated then challenged with JF820294.1 or used as non-challenged,
non-vaccinated controls. Serum was assayed
for TNF-α, IFN-γ, haptoglobin, serum
amyloid A, total, lipid-bound and protein-bound sialic
acid by standard procedures. All parameters except haptoglobin
showed significant differences from controls at different days post challenge.
Results suggest that a thermostable I-2 vaccine in prevented mortality and
reduced APP in chickens.
Key words: acute phase protein, village
chicken, Newcastle disease
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