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OJVRTM
Online Journal of Veterinary Research©
Volume 18(2): 91-100,
2014. Redacted 2018.
Incidence and
description of ovine pulmonary adenocarcinoma from 2000 abbatoir
lungs.
Reza
Kheirandish1*, Masoud Sami2, Hamideh Bashiri3
1,3Department(s) of
Pathobiology and 2Food Hygiene and Public Health School of
Veterinary Medicine, Shahid Bahonar
University of Kerman, Iran
ABSTRACT
Kheirandish
R, Sami M, Bashiri H., Incidence and description of
ovine pulmonary adenocarcinoma in abbatoir lungs
(2000), Onl J Vet Res., 18(2): 91-100, 2014. Ovine
pulmonary adenocarcinoma (OPA), known as Jaagsiekte, is a contagious lung tumor of sheep caused by beta-retrovirus
(Jaagsiekte sheep retrovirus: JSRV). Neoplastic transformation
occurs in pneumocyte type II and Clara cells. Diagnosis
of OPA is based on clinical history, pathologic findings and molecular
techniques. After inspection of 2000 lungs OPA was diagnosed in 16 (0.8%) lung
samples. Immunohistochemistry and polymerase chain reaction (PCR) were
performed on affected lungs and associated lymph nodes and revealed classic
(n=10/16) and atypical (n=6/16) forms. In the classic OPA, firm, white to
grayish nodules were grossly observed in the cranioventral
lobes. The cut surface of the lungs appeared wet with frothy fluid exudate in
airways. In the atypical OPA lesions were distributed as small clearly
demarcated nodules mainly in the diaphragmatic lobes without fluid in airways. Pneumocyte type II and Clara cells proliferated in an acinar and papillary pattern. The stroma of the atypical form asppeared
more infiltrated by connective tissue and mononuclear cells than the classic
form.
No metastatic lesions were observed in regional lymph nodes. JSRV capsid
protein was detected immunohistochemically in pneumocytes
type II, Clara cells, alveolar macrophages, lymphocytes and plasma cells of the
neoplastic regions and surrounding tissues.
In regional
lymph nodes, lymphoid follicles and infiltrated macrophages showed strong
positive results for JSRV-CA. PCR detected JSRV in all 16 affected lungs.
Key words: Ovine pulmonary adenomatous, histopathology,
immunohistochemistry, PCR, sheep.
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