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OJVRTM
Online Journal of
Veterinary Research©
Volume 17(11):592-599, 2013. Redacted 2017.
Serum
adenosine deaminase as a diagnostic marker of chronic infectious disease in
dogs.
Baharak Akhtardanesh (DVM. DVSc)1, Nima Ghalekhani(DVM)1,
Jalil Abshenas(DVM. DVSc)1,
Hadi Nematollahi (DVM) 2,
Hamid Sharifi (DVM ,PhD)3
1Department(s) of Clinical
Sciences and 3Food hygiene, Faculty of Veterinary Medicine, Shahid Bahonar University of
Kerman, 2Herbal and Traditional
Medicines Research Center, 2School of
Pharmacy and Biochemistry Department of
Kerman University of Medical Sciences, Kerman, Iran
ABSTRACT
Akhtardanesh B, Ghalekhani
N, Abshenas J,
Nematollahi H, Sharifi H.,
Serum adenosine deaminase as a diagnostic marker of chronic infectious disease
in dogs, Onl J
Vet Res., 17(11):592-599,
2013. Adenosine deaminase (ADA) is a cytoplasmic
enzyme essential for proliferation and differentiation of lymphocytes. Increased serum ADA results from
increased immune cell numbers whereas decreased values are associated
with immunodeficiency.
Serum levels of ADA as determined by an autoanalyzer kit in dogs with leishmaniosis, ehrlichiosis and brucellosis were compared with those in
healthy dogs. ADA values were 7.5±.0.8 in visceral leishmaniosis, 5.7±0.63 in ehrlichiosis, 5.3±0.24 in brucellosis and 2.26±0.25 IU/l in
normal control dogs. There was no difference in ADA values between diseased
dogs but values were higher compared with same values in normal control dogs.
Serum ADA level could be of some use as a marker for chronic infection in dogs.
KEY WORDS: Adenosine deaminase, Dog, Brucellosis, Ehrlichiosis, Visceral leishmaniosis.
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