Serum adenosine deaminase and inflammatory mediators in cattle naturally infected by Theileria annulata at rates of

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Online Journal of Veterinary Research©

Volume 18(6): 503-510, 2014. Redacted 2017.

Serum adenosine deaminase and inflammatory mediators in cattle naturally infected by Theileria annulata at rates of < 2, 2-4 and >4%

Seyed Mostafa Razavi ¹, Mahsa Khosravi¹, Ehsan Rakhshandehroo ¹, Mohsen Ghane², Saeed Nazifi *²

¹Departments of Pathobiologyand²Clinical Studies, School of Veterinary Medicine; Shiraz University, Shiraz, Iran

ABSTRACT

Razavi SM, Khosravi M, Rakhshandehroo E, Ghane M, Nazifi S., Serum adenosine deaminase and inflammatory mediators in cattle naturally infected by Theileria annulata at rates of < 2, 2-4 and >4%, Onl J Vet Res., 18(6): 503-510, 2014. Theileria annulata, a tick-transmitted protozoan parasite of cattle, invades bovine leukocytes and stimulates a variety of innate and adaptive immune responses in the host. Forty nine dairy Holstein cattle, naturally infected with T. annulata, were divided into 3 subgroups with parasitemia of <2%, 2-4% and >4%. Fifteen non-infected cattle were sampled as controls. Blood inflammatory cytokines (IL-1β, IL-6, IFN-γ and TNF-α) and Adenosine deaminase (ADA) activity were determined. Results showed decreases in red blood cells (RBCs), packed cell volume (PCV) and hemoglobin in infected cattle with increasing parasitemia. Serum cytokines and ADA activity increased greatly in infected cattle compared with controls.

Keywords: Bovine tropical theileriosis, cytokines, IFN-γ, TNF-α, Adenosine deaminase.

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