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OJVRTM
Online Journal of Veterinary Research©
Volume 20(10):638-645,
2016.
Impact of aflatoxin B1 from poultry on human hepatic
carcinoma.
Isamery A
Machado1,3, Vasco de Basilio1, Charly
Farfán1, Rafaela Altarugio1, Tarcisio Macedo1,2,
Adriano S Okamoto1, Noeme S Rocha2
1Institute
of Animal Production-UCV, 2Department
of Veterinary Clinics (Ornithopathology Service)
FMVZ-UNESP, 3Department of Veterinary Clinics (Pathology Service)
FMVZ UNESP.
ABSTRACT
Machado IA, de Basilio V, Farfán C, Altarugio R, Macedo T, Okamoto AS, Rocha NS., Impact of aflatoxin B1
from poultry on human hepatic carcinoma, Onl J Vet
Res., 20(10):638-645, 2016. Mycotoxins are secondary metabolites produced by toxic
fungi affecting animals and humans, of which ~400 occur in food processing. FAO
estimates that ~25% of the world's grains are contaminated by mycotoxins. In
birds, aflatoxin, Ochratoxin, T-2 toxin, diacetoxyscirpenol (DAS), Fumoninisina,
Citrinin y Cyclopiazonic
acid may induce teratogenic, mutagenic, and carcinogenic processes, and/or
depression of the immune system. Ingestion of poultry meat and viscera
containing mycotoxin is a common source of human poisoning and accumulation of
toxin in muscle and viscera of broiler chickens could trigger carcinogenic
processes. Aflatoxin B1 (AFB1) is a potent dietary hepatocarcinogen
in humans. Mutations and altered expression of tumor suppresser gene p53 has
been observed in liver tumors from patients exposed to high dietary AFB1.
Keywords: Mycotoxins, poultry, aflatoxin B1, hepatocarcinogen,
human.
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