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OJVRTM
Online Journal of Veterinary
Research©
Volume 23 (6):578-584, 2019.
Effect of L-Arginine and N-carbamoyl
glutamate on kidney and liver induced aflatoxin B1 histopathology in female
rabbits.
Bilal Abid-Almajeed Mikhlif and Adil Jabbar Atiyah
Veterinary Public Health, College of Veterinary
Medicine, University of Baghdad
ABSTRACT
Abd-Majeed Miklef B, Jabbar
Atiyah A., Effect of L-Arginine and N-carbamoyl
glutamate on kidney and liver induced aflatoxin B1 histopathology in female
rabbits., 23 (6):578-584, 2019. Authors report effect of arginine and N-Carbamylglutamate supplement on kidney and liver aflatoxin
induced toxicity in female rabbits. Four
groups of 7 rabbits each were fed basal diet with 4μg aflatoxin B1 (1), 4μg
aflatoxin and 1 hour later given 300mg Arginine (2) or 300mg N-carbamoyl
glutamate (3) daily for 7 weeks. Controls were fed basal diet (4). Rabbits were
sacrificed at 7 weeks for liver and kidney tissue microscopy. In livers of
rabbits given only aflatoxin, we observed extensive hemorrhagic foci, degeneration
and severe swelling of hepatocytes, with pyknosis, karyorrhexis and compression of sinusoids. In kidneys we found multiple hemorrhagic foci, amyloidiosis, swelling
of epithelial tubular cells, necrosis and inter-tubular vascular congestion. In those given N-carbamoyl glutamate we found central and portal vessel congestion and
coagulative necrosis and in kidneys similar to those given only aflatoxin. In rabbits
given aflatoxin with arginine we observed congestion of central
veins and focal vascular degeneration and necrosis but the parenchyma and
hepatic cords appeared mostly normal. Kidneys revealed mild degenerative
changes of tubular and glomerular mesangial cells. The findings suggest that
arginine may ameliorate histopathology of aflatoxin on liver and kidney in
rabbits.
Key words : Arginine,
N-carbamoyl glutamate,
aflatoxin B1, histopathological, rabbits.
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