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OJVRTM

Online Journal of Veterinary Research©

Volume 24(10): 573-577, 2020.

Effect of allium porrum on streptozotocin-induced diabetes mellitus hyperglycemia

and insulin resistance in male Sprague Dawley rats.

Seyed Jalil Massoumi¹, Ali Akbar Nekooeian², Nader Tanideh^2,3, Nahid Najafi^4*, Davood Mehrabani^3,5,6,7

¹Department of Nutrition and Food Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran, ²Department of Nutrition and Diet, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran, ³Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran, ⁴Stem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran, ⁵Burn and Wound Healing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran, ⁶Comparative and Experimental Medicine Center, Shiraz University of Medical Sciences, Shiraz, Iran, ⁷Li Ka Shing Center for Health Research and Innovation, University of Alberta, Edmonton, AB, Canada. *Correspondence: Nahid Najafi, Department of Nutrition and Diet, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran. Tel: +98-71-32332505, email: najafi.nahid70@yahoo.com

ABSTRACT

Massoumi SJ, Nekooeian AA, Tanideh N, Najafi N, Mehrabani D., Effect of allium porrum on streptozotocin-induced diabetes mellitus hyperglycemia and insulin resistance in male Sprague Dawley rats, Onl J Vet Res., 24(10): 573-577, 2020. Diabetes mellitus (DM) type 2 is prevalent worldwide. We report effect of hydro-alcoholic extract of Allium porrum on streptozotocin-induced diabetic rats. Diabetes was induced by intraperitoneal injection of 45mg/kg streptozotocin and 10mg/kg nicotinamide for 3 days. Then, groups of 10 diabetic male Sprague Dawley rats each, were gavaged daily for 42 days with 50, 100 and 200mg/kg of A. porrum, or 10mg/kg metformin. After 42 days, fasting blood sugar was assessed. Fasting blood glucose increased in all diabetic rats (P < 0.001) but in those gavaged high dose 200mg/kg A porrum we found a ~39% decline (P < 0.02) compared with diabetic controls. We found no effect on glucose tolerance or insulin resistance.

Key words: Allium porrum, Diabetes, Hyperglycemia, Hyperlipidemia, Rat.

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