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OJVRTM
Online Journal of
Veterinary Research©
Volume 20(2):55-64,
2016.
Histomorphometric
changes of diabetic rat retina after treatment with Aloe Vera gel.
Saberi M, Gholami S.
Department of Anatomy,
School of Veterinary Medicine, Shiraz University, Shiraz,Iran
ABSTRACT
Saberi M, Gholami S. Histomorphometric
changes of diabetic rat retina after treatment with Aloe Vera gel, Onl J Vet Res., 20(2):55-64, 2016. The effect of Aloe Vera
gel administration on retinal layer thickness in diabetic rats is
described. Groups of Sprague Dawley male
rats aged 12-16 weeks weighing 175±25gm were used as normal or diabetic treated and
diabetic controls. Diabetes was induced with 50mg/Kg streptozotocin
(STZ) IP. Blood glucose was measured before STZ administration and 24hrs
after. Treated diabetic animals were
then given 400mg/kg Aloe Vera extract. Rats were anaesthetized, eyes and
retinae were dissected, fixed in 4% glutaraldehyde and osmium tetroxid 1%, dehydrated and embedded in TAAB resin. 11µm sections were stained
with toluidine blue and viewed under light microscope. There was a reduction in
blood glucose and body weight in treated rats compared with diabetic ones. The
thickness of neural retina and its layers were also different. In the group
treated with Aloe Vera the thickness of retina and its layers retained their
normal histologic structures. Thickness
of different layers of diabetic retina could be affected with long term
treatment of Aloe Vera gel extract.
Keywords: Diabetes, Aloe
Vera, Retina, Streptozotocin.
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