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OJVRTM
Online Journal of
Veterinary Research©
Volume 24(9): 511-526, 2020.
Effect
of alpha lipoic acid on pesticide induced testicular toxicity in Albino rats.
Azza M Gawish.
Department of Animal Science, Faculty
of Science, Cairo University, Giza, Egypt
ABSTRACT
Gawish AM., Effect of alpha lipoic acid on pesticide
induced testicular toxicity in Wistar rats, Onl J Vet Res., 24(9): 511-526, 2020. Author describes effect of
alpha-lipoic acid (ALA) on hematology and testicular tissues in groups of 6
rats each gavaged 2mg/Kg 1/60LD50 chloropyrifos,
2.5 mg/km 1/200 LD50 fenitrothion with or without 200mg
ALA daily for 28 days. Blood and testis tissue were taken at 14 and 28 days for
hematology, histopathology and immunohistochemistry. In rats given pesticides
without ALA, we observed mild focal mild testicular hemorrhage, reduced
spermatogenesis, necrosis and atrophy. Masson-trichrome
stain revealed fibrosis and immunohistochemistry by TUNEL technique revealed
apoptotic cells between germ cells. Testes were depleted of acid phosphatase for
biosynthesis of testosterone. In rats given ALA with pesticide we found reduced
pathology in seminiferous tubules, spermatogenic germ
and interstitial cells and fibrosis but no apoptosis. Results suggest that the
antioxidant lipoic acid may reduce pesticide toxicity in testes of Wistar rats.
Keywords: Pesticides – Reproduction - Apoptosis -
Fibrosis – Antioxidants.
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