1994-2019. All Rights Reserved. Online Journal of Veterinary Research. You may not store
these pages in any form except for your own personal use. All other usage or
distribution is illegal under international copyright treaties. Permission to use any of these pages in any other way besides the
before mentioned must be gained in writing from the publisher. This
article is exclusively copyrighted in its entirety to OJVR publications. This
article may be copied once but may not be, reproduced or re-transmitted without
the express permission of the editors.
OJVRTM
Online
Journal of Veterinary Research©
Volume 22 (6):526-534, 2018.
Effect of acute aluminum chloride toxicity
on sperm and reproductive markers in Albino mice.
Anfal
Mahdi Mohammed, Bushra
Ibrahim AL-Kaisei, Taghreed
Jabbar Humadai, Eman
Hasham Al-Taee.
Department
of Veterinary Pathology, College of Veterinary Medicine, University of Baghdad,
Baghdad, Iraq.
ABSTRACT
Mohammed AM, AL-Kaisei
BI, Humadai
TJ, Al-Taee EH., Effect of acute aluminum chloride
toxicity on sperm and reproductive markers in Albino mice, Onl
J Vet Res., 22 (6):526-534, 2018. Effects
of intraperitoneal (IP) aluminum chloride (AL) on sperm and testis prostrate
and epididymal tissues
in Albino mice are reported. Medium lethal dose (LD50) for AL was
determined by probit in 8 groups of 9 mice each
injected 800 to 1500 mg/kg and estimate to be 1100mg/kg. Other groups of 18
mice each were then injected
an IP sub-acute dose of 221.83mg/kg IP, or saline (control) daily for 14
consecutive days. After the 3rd, 7th and 14th
day of dosing, groups of 6 mice each were sacrificed for sperm counts and
quality and microscopy of testis, prostrate and epididymis. Upon acute
toxic exposure, we found
significant (P<0.05) increases in defects in sperm with a decrease (P
<0.05) by day 14. Microscopy revealed degeneration of cells with necrosis,
hemorrhage, congestion, aspermia with lymphocyte
and macrophage
infiltration especially at day 14.
Key word: AlCl3 toxicity, male
Reproductive system, acute toxic exposure, Histopathological changes.