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OJVRTM
Online Journal of Veterinary
Research©
Volume
24(11): 665-671, 2020.
Effect of aluminum on behavior tests and brain
chemistry in female albino rats.
Razan F Hasa, Duraid A Abbas.
College of Veterinary Medicine, University of
Baghdad, Iraq.
ABSTRACT
Hasa RF, Abbas
DA., Effect of aluminum on behavior tests and
brain chemistry in female albino rats, Onl J
Vet Res., 24(11): 665-675, 2020. We
report effect of gavaged aluminium
on neural behavior and chemical markers in brain homogenate of 3 groups of 8 female
albino rats. Rats were gavaged 0.5 or 2.5 mg/kg (5
doses of 0.5mg/kg) daily for 42 days. Controls were given distilled water. Open
field, cliff avoidance, swimming, Y maze and negative geotaxis tests were
performed to assess behavior. Compared
with water controls, in rats given aluminum we found decreased (P < 0.05 for
all changes) open field arm entries with 0.5mg/kg (24%) or 2.5mg/kg (46%), defecation
increased 66-77% and urination ~66-81%. We found a ~30% decline in
acetylcholinesterase in rats given 0.5mg/kg but a 49% increase in those given
2.5mg/kg aluminum. We found large increases (51-62%) in brain homogenate malonyaldehide and large decline (-35 to -64%) in gluthathione in rats given aluminum suggestive of oxidative
stress with related free radical damage. Similarly we found increased brain
calcium 13-35%, magnesium 49-65%, zinc (29 – 63%) and AL (19-51%) consistent
with release of the components from damaged brain and muscle cells.
Keywords: Aluminum,
Neurobehavioral, Neurotransmitter, oxidation.
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