©1996-2014 All Rights Reserved. Online Journal
of Bioinformatics . You
may not store these pages in any form except for your own personal use. All
other usage or distribution is illegal under international copyright treaties.
Permission to use any of these pages in any other way besides the before mentioned must be gained in writing from
the publisher. This article is exclusively copyrighted in its entirety to OJB
publications. This article may be copied once but may not be, reproduced or re-transmitted without the express permission of the
editors. This journal satisfies the refereeing
requirements (DEST) for the Higher Education Research Data Collection
(Australia). Linking: To link to this page or any pages
linking to this page you must link directly to this page only here rather than
put up your own page.
OJBTM
Online Journal of
Bioinformatics ©
Volume 15 (1): 133-140, 2014
ASPMP –
A Biochemical Pathway Resource for Aspergillus terreus NIH2624
T.K. Subazini (PhD) and G. Ramesh Kumar*(PhD)
AU-KBC Research Centre, MIT Campus of Anna University, Chromepet, Chennai, India.
ABSTRACT
T.K. Subazini
(PhD) and G. Ramesh Kumar* ASPMP – A Biochemical Pathway Resource for Aspergillus terreus NIH2624, Onl J Bioinform 15 (1): 133-140, 2014. Reconstruction of genome-scale
metabolic pathway is an essential task for facilitating various analysis and simulation
to understand cellular processes in Aspergillus terreus. The study of biochemical pathways in A. terreus
enables to identify key regulators for modification to enhance the yield of
industrial product lovastatin.
ASPMP (Aspergillus terreus metabolic
pathway) database is developed for
the analysis of pathways in A. terreus NIH2624. The database is created by BLASTing protein sequences of A. terreus against closely related Aspergillus species such as A. oryzae, A. niger and A.nidulans to
generate an initial set of reactions. In addition, enzymes from the functional reannotation data using integrated reannotation
approach is used for updating the reaction set. From the updated reaction set,
metabolic pathways are constructed using Graphviz and
are stored in ASPMP. This database (http://aspmp.bioinfo.au-kbc.org.in/) provides
option for search using an EC number or pathways and for creating new networks for
a set of reactions with their catalyzing enzymes
using ASPMP.
Keywords: Aspergillus terreus, reannotation, network expansion, pathway reconstruction