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OJVRTM
Online Journal of
Veterinary Research©
(Including
Medical and Laboratory Research)
Established 1994
ISSN 1328-925X
Volume 27 (2): 85-05, 2023.
Disposition of cyanidin
phytonutrients in elder berry extract.
Bill Roschek, Randall S Alberte
HerbalScience Group LLC., Naples FL 34110, USA
ABSTRACT
Roschek B Jr., Alberte RS, Disposition of cyanidin phytonutrient
in elder berry extract. Onl J Vet Res.,
27(2): 85-95, 2023. Disposition of flavonoid
phytonutrients in elder berry extract was assessed by LC-MS or DART TOF-MS.
Serum-urine cyanidin from lozenges were monitored by
LC-MS in 6 individuals whereas DART TOF-MS was done to determine serum cyanidin and other flavonoids when delivered as a
slow-dissolve lozenge or in drink from one subject. With lozenges, serum cyanidin varied 3.1 (LC-MS) and 5.4 nmol
L-1 (DART TOF-MS), with 2.7 and 4.7% bioavailability (BA), whereas averionol methylated flavonoid 23 nmol
L-1 with 10.5% BA, Tristenonol esterified
flavonoid and Istrocyanidin 3.9 nmol
L-1 (8.6% BA) and 7.5 nmol L-1
(19.7% BA), respectively. When consumed in drink BA of cyanidin
declined 20-fold (0.2% BA), Averionol and Istrocyanidin 2-fold (4.6 and 10.8% BA, respectively)
compared with lozenges suggesting primary uptake in oral cavity whereas BA of Tristenonol increased 2-fold (18.8% BA) in drink compared with lozenge pointing to small
intestine as primary uptake site.
Key Words: Elder berry, DART TOF-MS, Cyanidin,
Influenza.
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