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OJVRTM
Online Journal of Veterinary Research©
Volume
19(3): 190-211, 2015, Redacted 2017.
Synthesis and
anti-mycobacterial activity of multicomponent Biginelli
reaction catalysed by surfactant in aqueous media.
Durga Prasad Beda*a,b, Girija Sastry Vedulab, Jayasimha Rayalu Daddamc
aDepartment(s) of Pharmaceutical Chemistry, Bhaskar
Pharmacy College, Yenkapally, Moinabad, Rangareddy, Telangana,
bPharmaceutical Chemistry, College
of Pharmaceutical Sciences, Andhra University, Vishakapatnam,
Andhra Pradesh, cBiotechnology, JNTUA, Anantapuramu, Andhra Pradesh, India
Prasad
Beda D, Sastry
Vedulab G, Rayalu DaddamJ., Synthesis and anti-mycobacterial activity of
multicomponent Biginelli reaction catalysed
by surfactant in aqueous media, Onl J Vet Res., 19(3): 190-211, 2015. A method for the synthesis of
4-aryl-3,4-dihydropyrimidine-2(1H)-ones/thione (Biginelli reaction)
from 1,3-dicarbonyl compound, substituted aldehydes and urea/thiourea in the presence of
sodium dodecyl sulphate (SDS) novel catalyst
under two experimental conditions is described. Using these methods title
compounds were produced in high yield. Synthesized compounds were evaluated for
their antibacterial, antifungal and anti-tubercular activity. 5-(ethoxycarbonyl)-4-(4-chlorophenyl)-6-methyl-3,4-dihydropyrimidine-2(1H)-thione and 5-(carboethoxy)-4-(4-chlorophenyl)-6-methyl-3,4-dihydropyrimidine-2(1H)-one,
showed excellent activity due to chlorine at C-4 of the phenyl ring.
Keywords: Pyrimidine; sodium dodecyl sulphate; antimicrobial; antitubercular
activity
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