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OJVRTM
Online Journal of Veterinary Research©
(Including
Medical and Laboratory Research)
Established
1994
ISSN
1328-925X
Volume
29 (5): 306-313, 2025.
Tyrosine hydroxylase immunoreactivity in bladder of
cats with cystitis.
Reche A,
Buffington TCA, Hagiwara MK, Daniel AGT.
aDepartment of Medical Clinics
Faculdade de Medicina Veterinaria, Universidade de Sao Paulo, Brazil b.
Departmet of Veterinary Clinical Sciences, College of Veterinary Medicine, Ohio
State University, Columbus, Ohio-USA.
ABSTRACT
Reche A, Buffington TCA, Hagiwara MK, Daniel
AGT., Tyrosine
hydroxylase immunoreactivity in bladder of cats with cystitis., Onl J Vet Res.,
29 (5): 306-313,
2025. We report identification and quantity sympathetic nervous fibers in urinary
bladder of 6 healthy cats and 6 with interstitial cystitis without clinical
signs for 6 months before study. All cats were euthanized and immediately
perfused transcardially with Krebs-Ringer and 4% paraformaldehyde solutions. Urinary
bladders were collected and frozen at -70C. Tissue slides were processed for
immunohistochemistry by avidin-biotin to localize neuronal tyrosine hydroxylase.
Compared with controls, in cats with cystitis we observed increased sympathetic
nervous fibers in lamina propria and muscular layer of urinary bladder which may
be induced by neurogenic inflammation.
KEY WORDS:
interstitial cystitis, cats, tyrosine hydroxylase, urinary bladder.
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