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OJVRTM
Online Journal of Veterinary Research
Volume 4: 1-20, 2000. Redacted
2018.
A caprine breast model for testing a novel
balloon brachytherapy device
J. Paul
Spurlock, D.V.M., M.P.H. a, Robert R. Kuske,
Jr., M.D. b, William J. McKinnon, M.D. c, Ed Moran,
L.A.T.G. a, Laura Sabo, B.S. d and H. W.
Taylor, D.V.M., Ph.D. e
a Department of Vivarial
Science & Research, Tulane University School of Medicine, 1430 Tulane
Avenue, New Orleans, LA 70112 b Department of Radiation Oncology, Ochsner Clinic and Tulane University School of Medicine,
New Orleans, LA 70112 c Department of Surgery, Tulane University,
School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112 d Proxima Therapeutics, Inc., 1111 Alderman Drive, Suite 280,
Alpharetta, GA 30005 e Department of Pathology, Louisiana State
University School of Veterinary Medicine, Baton Rouge, LA 70803Address for
correspondence: J. Paul Spurlock, D.V.M., M.P.H., Tulane University
School of Medicine, Department of Vivarial Science
& Research,SL62, 1430 Tulane Avenue, New Orleans, LA 70112. Email: pspurlo@tmcpop.tmc.tulane.edu
ABSTRACT
Spurlock JP, Kuske R, McKinnon WJ, Moran E, Sabo L,
Taylor HW A caprine breast model for testing a novel balloon brachytherapy
device, Onl J Vet Res., 4: 1-20, 2000. We describe a caprine breast model developed to
evaluate the Proxima GliaSite®
applicator as a prototype device design for brachytherapy treatment after
mammary tumor resection. Testing the novel interstitial balloon applicator
required an animal breast model of appropriate size and structure to respond to
lumpectomy (with or without device implantation) at gross and cellular levels
comparable to human breast tissue. The model would need to allow the detection
of seroma or hematoma formation, foreign-body reaction, or inflammation in
response to the implanted device, as well as allow evaluation of balloon conformance
and its effect on a lumpectomy cavity. The female goat was suggested as an
appropriate animal model for this study because goat breast and mammary tissue
characteristics can bear particular similarity to that of humans. The female
goat was an excellent experimental subject within the construct of this study,
and the caprine breast model proved well suited for evaluating the test device in vivo. Based on the results of
this project, this breast model will be used in future studies to evaluate a
balloon catheter device of similar design in conjunction with low-dose
radiation (LDR) and high-dose radiation (HDR) boost therapy on mammary tissue
after tumor resection.
KEY WORDS: Caprine breast model; goat animal model;
mammary tumor resection; interstitial brachytherapy; boost therapy; balloon
applicator; balloon catheter; GliaSite® ; Proxima
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