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OJVRTM

Online Journal of Veterinary Research©

(Including Medical and Laboratory Research)

Established 1994

ISSN 1328-925X

 

Volume  29 (10): 612-620, 2025.


Effect of cold exposure on cardio-hepatic mitochondrial malonilaldehyde and superoxide dismutase pulmonary hypertensive syndrome of broilers

 

 Sijun Yang, Dingzhong Guo,  Baoan Yao

 

College of Animal Science and Veterinary Medicine, Huazhong Agricultural University, Wuhan, China

 

ABSTRACT

Yang S, Guo D, Yao B., Effect of cold exposure on cardio-hepatic mitochondrial malonilaldehyde and superoxide dismutase pulmonary hypertensive syndrome of broilers, Onl J Vet Res., 29 (10): 612-620, 2025. Pulmonary Hypertension Syndrome (PHS) in broilers is associated with increased malonyl-aldehyde (MDA) and decreased superoxide-dismutase (SOD) levels in tissues suggesting a causal relationship between oxidative stress and pathology. We studied 2 groups of two hundred 21 day old broilers reared at 24 and 12Co, respectively compared up to 49 days of age. In broilers exposed to 12Co, right (RV) total ventricle (TV) weight ratio increased 37%, cardio-hepatic SOD activity decreased 25-36% and cardio-hepatic MDA increased 38-40% suggesting that cold exposure induced cardio-hepatic mitochondrial membrane oxidative stress by free radicals.

Key words: Ascites syndrome, Mitochondria, Malonyl-aldehyde, free radicals, antioxidants.


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