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OJVRTM
Online Journal of Veterinary Research©
Established 1994
ISSN 1328-925X
Volume 22 (9):847-850, 2018.
Effect of oral cadmium chloride on glutathione
and malondialdehyde
in kidney, liver and
brain tissues of young female albino rabbits.
Khalid Ahmed Hadi , Wasan
Sarhan Oubied, Dakheel Hussein Hadree.
Department
of Physiology, Biochemistry and Pharmacology, Faculty of Veterinary Medicine, University
of Tikrit, Iraq
ABSTRACT
Hadi KA, Oubied
WS, Hadree DH., Effect of oral cadmium chloride on glutathione
and malondialdehyde in kidney, liver and brain
tissues of young female albino rabbits, Onl J Vet
Res., 22 (9):847-850, 2018. Cadmium can induce severe changes in tissues due to lipid peroxidation
and free radical generation. Six 2-3 month old female albino rabbits were
supplied 25mg/L cadmium in drinking water over 45 days. At 45 days rabbits were
sacrificed for glutathione, glutathione peroxidase and malondialdehyde
levels in kidney, liver and brain tissues. Controls were given water without
cadmium. Compared with controls (P < 0.05), glutathione was 46-66% and
glutathione peroxidase 45-75% lower, but malondialdehyde
15-38% higher in those tissues. Glutathione and glutathione peroxide decreased
most in liver (66-75%), but malondialdehyde increased
most in brain tissue (38%)
Key words :
cadmium chloride, female rabbit raw data provided.