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OJVRTM
Online Journal
of Veterinary Research©
Volume 17 (6): 329-338, 2013. Extensively Redacted 2017.
Ultrastructure of vascular endothelium of
premalignant and malignant cervix lesions in patients infected by human
papilloma virus.
Ivis J Graterol* ¹, Hector J Finol ², Maria Correnti ³, Maira Įvila ³.
¹Department of Normal and
Pathologic Morphology, Carabobo University, ²Center for Electron Microscopy, Central
University of Venezuela, ³Institute of Hematology and Oncology, Laboratory of
Genetics, Caracas, Venezuela
ABSTRACT
Graterol
IJ. Finol HJ, Correnti M,
Įvila M., Ultrastructure of vascular endothelium of premalignant and malignant
cervix lesions in patients infected by human papilloma virus.. Onl J Vet Res., 17 (6): 329-338, 2013. Ultrastructure of vascular
endothelium of premalignant and malignant lesions of the uterine cervix in
patients infected by human papilloma virus (HPV) is described. PCR was performed to detect HPV. A NIC I
sample with HPV type 6 infection showed a capillary
with a reduplicated basement membrane and widened endothelial cell cytoplasm. A
uterine NIC II sample infected with HPV type 16 revealed a mastocyte and
abundant collagen fibers. A NIC III sample with infection by HPV type 16 showed
capillary basement duplication with endothelial and pericyte
cytoplasms which appeared widened. In another pericyte there was a pinocytotic vesicle. In a sample of
invasive cervix cancer with HPV type 16, a widened endothelial cell cytoplasm
showed prolongations into the lumen with the presence of primary lysosomes and
pinocytotic vesicles. HPV11 was identified and both endothelial cytoplasm
prolongations into the lumen and thickening of the endothelial wall were
evident. The findings suggested that changes in microvascular tissue in
premalignant lesions with thickening of the endothelial capillary walls in
malignant lesions indicate activation of angiogenesis.
Key
Words: Ultrastructure, Endothelial vascular, Cervical
cancer, HPV.
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