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OJVRTM
Online Journal of Veterinary Research©
Volume 18(2):145-150, 2014.
Effects of high doses of Citicoline on hepatic
and renal markers in beagle dogs
Mehdi Saberi (DVM, PhD)1,2,
Elham Mohebbi (DVM, MPH)3,
Samira Hosseini Hooshyar (DVM)4, Parham Razavi Ebrahimi (DVM)1,
Amin Paydar (DVM)1
1Department of
Clinical Studies, School of Veterinary Medicine, Shahid
Bahonar University of Kerman, 2Research
Center for Social Determinants of Health, Institute for Futures Studies in
Health, 3Research Center for Modeling in Health, Institute for
Futures Studies in Health, 4Regional Knowledge Hub, and WHO
Collaborating Centre for HIV Surveillance, Institute for Futures Studies in
Health, Kerman University of Medical Sciences, Kerman, Iran
ABSTRACT
Saberi M, Mohebbi E, Hooshyar SH, Ebrahimi PR, Paydar A., Effects of high
doses of Citicoline on hepatic and renal markers in
beagle dogs, Onl J Vet Res., 18(2):145-150, 2014. Cytidine diphosphate choline or citicoline is involved in cell membrane biosynthesis and
has been used to improve cognition, stroke rehabilitation and brain edema. Hepatic and renal markers were evaluated in
Beagle dogs given citicoline. Seven beagle dogs were
injected IV 500mg and 1000mg per dog Citicoline every
12 hours in two courses of 15 days each with a 14 day washout period in
between. Blood samples were collected at the 16th and 45th
day for hepatic and renal markers including ALP, ALT, AST, GGT, Random Bile
Acid, LDH, Total Billirubin, Direct Billirubin, Total Protein, Cholesterol, BUN, Cr and USG.
There was no significant difference between the 2 doses of Citicoline
except with ALT, ALP and random bile acid which increased in dogs given 1000mg
but were still within normal range. The results should be interpreted with
caution as the same dogs were given repeat different dose treatments and ages
ranged between 3 and 4 years. Results suggest that long-term usage of IV 1000mg
every 12 hours daily for 15 days in 3-4 yr old
Beagles could have the potential to induce hepatic injury.
Key words: Cyticholine, Beagle dog, Liver, Kidney, Biochemical factors
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