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OJVRTM
Online Journal of Veterinary Research©
Volume 21(11):751-755, 2017.
Effect of Citrus aurantifulia
seed extract cream on cutaneous wound healing in male Sprague-Dawley rats
Mohammad Mahdi Zangeneh1*, Milad Alahmoradi1, Masoud
Shamohammadi1, Milad Khazaei1,
Amir Amiri-Paryan2, Adel Akbari1,
Reza Tahvilian3, Akram Zangeneh2, Rohallah
Moradi3
Department(s) of 1Clinical and 2Basic Sciences, Faculty
of Veterinary Medicine, Razi University,
Kermanshah, Pharmaceutical Sciences Research Center, School of Pharmacy, Kermanshah
University of Medical Sciences, Kermanshah, Iran ". *Corresponding Author: Mohammad Mahdi Zangeneh, *Email: zangeneh1371@yahoo.com
ABSTRACT
Zangeneh MM, Alahmoradi M, Shamohammadi
M, Khazaei M, Amiri-Paryan
A, Akbari A, Tahvilian
R, Zangeneh A, Moradi R.,
Effect of Citrus aurantifulia seed extract cream on
cutaneous wound healing in male Sprague-Dawley rats, Onl
J Vet Res., 21(11):751-755,
2017. Several plant products have been used in treatment of wounds
over the years. Citrus aurantifulia (CA) has
been used for antioxidant, anti-inflammatory, antipyretic, antibacterial and
anti-fungal properties. Authors describe effect of CA seeds aqueous extract
cream on cutaneous wound healing in Sprague-Dawley male rats.
Full-thickness excisional wounds (2×2 cm) were performed on dorsum of 32 rats
and treated with 1ml basal Eucerin cream, 1ml CA
aquatic extract cream 10%, and 1ml tetracycline (3%) for 20 days. Animals of
each group were euthanized at 20 day post-injury and wounds were assessed
through gross and histopathological analyses. Size of wounds, re-epithelialization and epithelial formation in
rats given CA were significantly different compared with other groups (p<0.05). Number of lymphocytes
declined but fibrocytes and fibroblasts increased in
CA group at 20 days (p<0.05). Results suggest that CA seed aqueous
extract cream applied topically may promote healing.
Keywords: Citrus aurantifulia, seeds, aqueous extract; cream; wound healing.