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Online
Journal of Veterinary Research©
Volume 11 (3) :24-31, 2007. Redacted 2018.
Pathogenesis of anemia in Cocker Spaniels with chronic renal failure
Notomi MK1, Kogika MM1, Esaine LL1, Coelho BMP2, Wirth lVFB2, Simões DMN2, Hagiwara MK1
1 Department of Clinical Medicine of the School of Veterinary Medicine and Animal Science, University of São Paulo (FMVZ-USP), Brazil
2Veterinary Teaching Hospital – HOVET-FMVZ-USP, 87, Orlando Marques
Paiva St., Cidade Universitária, São Paulo, Brazil.
ABSTRACT
Notomi MK, Kogika MM, Esaine LL, Coelho BMP,
Wirth lVFB, Simões DMN,
Hagiwara MK, Pathogenesis of anemia in Cocker Spaniels with chronic renal
failure, Onl J Vet Res., 11 (3) : 24-31-8, 2007. The
pathogenesis of anemia in cocker spaniel dogs with (n =15) or without (n=15)
chronic renal failure is described. Erythrograms,
serum erythropoietin (EPO) erythrocyte-bound immunoglobulin or complement using
Coombs test were evaluated in both groups. No difference in EPO serum
concentration was observed between the groups with CRF, or between sex and age.
A positive Coombs test was found in 1 CRF dog. Positive correlation were found
between serum concentrations of creatinine and phosphorus (P<0.001) and
negative correlations between packed cell volume and serum creatinine
(P<0.0001), and packed cell volume with serum phosphorus (P<0.0001). The
development of anemia correlated with increased serum concentration of
creatinine and phosphorus. Immunomediated haemolysis, may also contribute to causing anemia. The
presence of non-regenerative anemia could indicate a relative deficit of EPO in
dogs with CRF, although absolute values were close to the concentrations
observed in healthy controls (15).
KEY
WORDS: anemia, chronic renal failure, erythropoietin,
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