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OJVRTM
Online Journal of Veterinary Research©
(Including Medical and
Laboratory Research)
Established 1994
ISSN 1328-925X
Volume 29 (8): 499-506, 2025.
Chronic renal failure and anemia in 15 Cocker spaniels.
Notomi MK, Kogika MM, Esaine LL, Coelho BMP, Wirth lVFB Simões DMN, Hagiwara MK.
Department of Clinical Medicine of the School of Veterinary Medicine and Animal Science, University of São Paulo,
Veterinary
Teaching Hospital , Cidade Universitária, São Paulo, Brazil
ABSTRACT
Notomi MK, Kogika MM, Esaine LL, Coelho BMP, Wirth lVFB, Simões DMN, Hagiwara MK, Chronic renal failure and anemia in 15 Cocker spaniels Onl J Vet Res., 29 (8): 499-506, 2025. The pathogenesis
of anemia in cocker
spaniel dogs with chronic renal failure (CRF) was evaluated in 15 dogs with CRF
and 15 normal controls. Erythrograms, serum
erythropoietin (EPO)
erythrocyte-bound immunoglobulin or complement by Coombs test
were evaluated in both groups. Compared with controls, in dogs with CRF, Packed
cell volumes (PCV) and hemoglobin (Hg) declined ~53%, whereas creatinine
increased 7 fold and phosphorus ~74%. A positive Coombs test was found in 1 CRF
dog. Positive correlation were found between serum concentrations of creatinine
and phosphorus (P<0.001) and negative correlations between packed cell volume
and serum creatinine (P<0.0001), and packed cell volume with serum
phosphorus (P<0.0001). The development of anemia correlated with increased
serum concentration of creatinine and phosphorus. Immuno-mediated hemolysis,
may also contribute to causing anemia. The presence of non-regenerative anemia
could indicate a relative deficit of EPO in dogs with CRF, although absolute
values were close to the concentrations observed in the healthy dogs.
KEY WORDS: anemia, chronic renal failure, erythropoietin.
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