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OJBTM
Online Journal of Bioinformatics ©
Volume 13(2):314-330, 2012.
Characterization of Coilin
protein nucleotide binding region in Homo
sapiens
Aubhishek Zaman
Molecular Biology Laboratory, Department of
Biochemistry and Molecular Biology and
Department of Genetic engineering and Biotechnology, University of Dhaka,
Bangladesh,.
Zaman A., Characterization of Coilin protein
nucleotide binding region in Homo sapiens, Online J Bioinform,
13(2):314-330,
2012. Coilin proteins are an integral part of Cajal
bodies, subnuclear structures responsible for
biogenesis of telomerase and ribonucleoprotein. In silico
nucleotide binding region of Coilin is described. The
region showed a long trench-like groove suggesting presence of a long
nucleotide sequence as ligand. Sequence variation in the region may account for
variation in embryogenesis across a diverse array of species. Variation may
have occurred over the course of evolution as the sequence might be responsible
for binding the nucleotide sequence non-specifically. The stretch of positive
charges found in the region may be significant.
Keywords: Coilin
protein, Cajal body, Ribonucleoprotein,
Dot matrix plot, Xenopus laevis,
Molecular docking