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OJVRTM
Online Journal of Veterinary Research©
Volume 24 (4):257-262, 2020.
Effect
of Colicin V on E. coli K99 induced diarrhea in
infant mice.
Fatemeh Golestan1, Yahya Tahamtan2*,
Elham Moazemian3
Department
(s) 1Bacteriology, Azad University, Jahrom
branch 2Razi Vaccine and Serum Research Institute, Shiraz,3Azad University
Science Research Fars branch, Shiraz, Iran.
ABSTRACT
Golestan
F, Tahamtan Y, Moazemian
EM., Effect of Colicin
V on E. coli K99 induced diarrhea in infant mice. Onl
J Vet Res., 24 (4):257-262, 2020. Effect of E. coli colicin V on diarrhea caused by E. coli K99 in
infant mice is described. Genotypes E coli from cattle were verified by PCR for
colicin genes. Six groups of 8 balb-c
infant mice each were gavaged 1/2ml Colicin (colicin controls), E.
coli K99 (E coli controls), Colicin first and after
E. coli K99 (treated before) or vice versa (treated after). Mice were monitored
for mortality for 7 days and gastrointestinal tract sections were excised for bacteriology
and histopathology. All colicin controls survived but
only one E coli K99 (~12%) control mouse did. In those given colicin before challenge with E coli K99 we found 88% survival whereas in those given the colicin after challenge survival was only 70%. We found no pathology in mice given colicin per se or
in those treated before challenge.
Keyword: Infant
mice, Colicin-V, E. coli K99.