©2026-2038 All Rights Reserved. Online Journal of Veterinary
Research. You may not store these
pages in any form except for your own personal use. All other usage or
distribution is illegal under international copyright treaties. Permission to use any of these pages in any other way besides the
before mentioned must be gained in writing from the publisher. This
article is exclusively copyrighted in its entirety to onlinejournals@gmail.com
publications.. This article may be copied once but may
not be, reproduced or
re-transmitted without the express permission of the editors.
Linking: To link to this page or any pages linking to this page you must link
directly to this page only here rather than put up your own page.
OJVRTM
Online Journal of Veterinary Research©
(Including
Medical and Laboratory Research)
Established
1994
ISSN
1328-925X
Volume 30 (5): 320-340, 2026.
Compact bone repair with or
without osteoblsts in rabbits.
Kamran Kaveh,
Rashid Ibrahim, Tengku Azmi
Ibrahim, Mohd Zuki Abu
Bakar.
Faculty of Veterinary Medicine,
University of Putra Malaysia, Selangor, Malaysia.
ABSTRACT
Kamran
Kaveh K, Ibrahim R, Ibrahim TA, Abu Bakar MZ, Compact
bone repair with or without osteoblsts in rabbits.. Onl J Vet Res, 30 (5):
320-340, 2026. We report effects of autologous osteoblasts and corticocancellous bone graft for repairing compact bone of critical
size defect in normal and osteoporotic bone. Bone marrow-derived mesenchymal
stem cell of 6 rabbits were cultured, differentiated into osteoblasts and
seeded into scaffold of corticocancellous bone graft
and implanted in normal and osteoporotic rabbits. Eight week radiographs monitored
osteogenicity. By 8 weeks rabbits were euthanized and
implants excised for gross, histological and scanning electron microscopy. Bone graft per
se formed through creeping substitution at margin and osteogenesis
at centre including osteogenesis, conduction, and
induction. For cortico cancellous bone, formation
with thin bone trabecullae penetrated entire defect
was completely osteoporotic. Compared
with corticocancellous bone autograft, we find that corticocancellous bone graft with autogenous marrow-derived
osteoblasts was ~39-51% (P < 0.05) more
efficient
Keywords: Bone tissue engineering, corticocancellous bone graft, critical sized defect, osteoblasts,
osteoporosis, rabbit.