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OJVRTM
Online Journal of Veterinary Research©
(Including Medical
and Laboratory Research)
Established 1994
ISSN 1328-925X
Volume 26 (9): 651-660, 2022.
Functional analysis
of Trypanosoma congolense
P74 gene by double strand RNA
interference.
Waren N. Baticados1 DVM PhD, Noboru Inoue2 DVM
PhD, Chihiro Sugimoto3 DVM PhD,
Hediyuki Nagasawa2 DVM PhD and Abigail M Baticados1
DVM
1 College
of Veterinary Medicine,University of the Philippines
Los Baños, Laguna; 2National Research
Center for Protozoan Diseases, Obihiro University of
Agriculture and Veterinary Medicine, Obihiro, Hokkaido 8555, Japan and 3 Laboratory
of Infectious Diseases, Graduate School of Veterinary Medicine, Hokkaido
University, Sapporo 060-0818, Japan.
ABSTRACT
Baticados WN, Inoue
N, Sugimoto C, Nagasawa
H, Baticados AM., Functional analysis of Trypanosoma congolense P74 gene by double strand RNA interference, Onl J Vet Res., 26 (9): 651-660, 2022. Trypanosoma congolense RNA interference cell lines were used to determine
function of Trypanosoma congolense P74
gene by double strand RNA
interference. The present study
strongly indicates and further verified the data of the previous research that,
P74 gene is stage-specific and the
expression is developmentally up-regulated in Trypanosoma congolense bloodstream
forms. The inability to determine the function due
to the stage-specific expression of the gene still contributed to the
understanding of the nature of the gene and double strand RNA interference in
trypanosomes. The study further stress that T. congolense is still amenable to double strand
RNA interference and is an excellent model species to conduct laboratory
studies in stage-specific gene expression.
Key
words: Double strand RNA Interference, Trypanosoma
congolense, putative ABC1 family protein, procyclic
form.
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