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Online Journal of Veterinary Research©

 

Volume 18(11): 905-913, 2014.

In vitro activity of p-coumaric acid on Aeromonas hydrophila of diseased carp.

 

Shirali T 1*, Tabandeh MR2, Alishahi M1, Ghorbanpoor M3, Akhlaghi M4

 

1 Clinical Sciences,  Aquatic Animal Health,  2 Biochemistry and Molecular Biology, 3Pathobiology, School of Veterinary Medicine, Shahid Chamran University of Ahvaz, 4 Aquatic Animal Health, Sschool of Veterinary Medicine, Shiraz University,  Shiraz, Iran

 

ABSTRACT

 

Shirali T, Tabandeh MR, Alishahi M, Ghorbanpoor M, Akhlaghi M., In vitro activity of p-coumaric acid on Aeromonas hydrophila of diseased carp, Onl J Vet Res., 18(11): 905-913, 2014. We describe dose dependent antibacterial effects of p-coumaric acid on Aeromonas hydrophila isolates obtained from diseased fish in cyprinid farms. Isolates were confirmed by PCR and antibacterial activity of p-coumaric acid, oxytetracycline and florfenicol measured by disc diffusion and microdilution. In 1.8 and 2 mg/mL p-coumaric acid mean diameters of inhibition were 17 and 20.8 mm respectively. P-coumaric acid exhibited antibacterial action against all tested isolates with mean inhibitory and minimum bactericidal concentration of 2 and 2.17 mg/ml, respectively.  Antibacterial activity increased with increasing concentrations of p-coumaric acid in media. The findings suggest that p-coumaric acid inhibits A. hydrophila and could be used for treatment of bacterial infections in fish.

 

Key words: p-coumaric acid, antibacterial activity, disk diffusion, microdilution method, Aeromonas hydrophila.

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