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OJVRTM
Online
Journal of Veterinary Research©
Volume 24 (4):230-242, 2020.
Effect of papyrus protein and crab shell
scaffold without osteoblasts on bone healing in dogs.
Saad
Hassan Zebon1 Bahaa F
Hussein3, Mohammed Jawad Eesa2
Department(s)
of 1,2Surgery, 3Anatomy, College of Veterinary Medicine,
University of Baghdad, Baghdad, Iraq.
ABSTRACT
Zebon SH,
Hussein BF, Eesa MJ., Effect of papyrus
protein and crab shell scaffold without osteoblasts on bone healing in dogs, Onl J Vet
Res., 24 (4):230-242, 2020. Critical-size
bone defects normally do not heal when left untreated. We describe a porous
biodegradable scaffold without osteoblasts. The scaffold was then monitored for
tibia repair implant in dogs. Serum alkaline phosphatase and calcium were
determined at days 0, 1, 7, 10, 20, 30, 60 and 90 of implant. In dogs we found
the implant induced bone formation in a 1 cm e defect in the tibia. In dogs
with scaffold bone union occurred by 3 months in contrast with non-implanted controls. Compared with controls serum
alkaline phosphatase in dogs with scaffold were ~33 to 41%s higher (P < 0.05)
between days 20 and 90 suggesting osteoblastic and osteogenic activity
associated with bone growth. We surmise that our scaffolds promoted
osteoblastic activity without need for osteoblasts seeding.
Key word: Al-kharit papyrus,
Crab Shell, Tissue Engineering, Bioceramic Scaffold,
Dogs.
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