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OJBTM
Online Journal of Bioinformatics©
Volume 9 (1): 12-20, 2008
Elucidating the role of CREBBP co-activator in erythroid differentiation by literature mining and analysis
Iyer J1*, Raghunath A1, Bhate J1
and Wong.L2
1
Molecular Connections Pvt. Ltd, Kandala Mansions,
#2/2 Kariappa Road (South Cross Road), Basavanagudi, Bangalore – 560004, India and 2National
Institute of Singapore, Science Drive 2,
Singapore 117543, Republic of Singapore
ABSTRACT
Iyer J, Raghunath A, Bhate J, Wong L., Elucidating
the role of CREBBP co-activator in erythroid
differentiation by literature mining and analysis, Online J Bioinformatics 9 (1): 12-20, 2008. Differentiation of pluripotent
hematopoietic stem cells into mature circulating
erythrocytes are coordinated by a set of lineage- and tissue specific transcription
factors. The two highly related nuclear proteins CREB binding protein (CBP or
CREBBP) and p300 are co-activators that possess histone
acetyltransferase activity, play a central role in
the integration of transcription signals involving diverse cellular processes
and differentiation pathways such as hematopoiesis,
embryogenesis and so .We have been using literature mining successfully to
unravel various biological processes and provide a concise view of regulation
of the physiological networks. An interaction database NetProTM
was used as a source of all interactions in this study. By further network
analysis, CBP is shown as a molecular integrator of hematopoietic
differentiation. Several transcription factor nodes through which the master
regulatory cofactor CBP binds and modulates the expression or activity of
downstream genes involved in erythrocyte differentiation have been elucidated.
Key words: CBP, CREBBP, erythrocyte differentiation,
transcription factor network, literature mining
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