©1996-2018. All
Rights Reserved. Online Journal of Veterinary Research .
You may not store these pages in any form except for your own personal use. All
other usage or distribution is illegal under international copyright treaties. Permission to use any of these pages in any other way besides the
before mentioned must be gained in writing from the publisher. This
article is exclusively copyrighted in its entirety to OJVR. This article may be
copied once but may not be, reproduced or re-transmitted without the express
permission of the editors. This journal satisfies the refereeing requirements
(DEST) for the Higher Education Research Data Collection (Australia). Linking:To link to this page or
any pages linking to this page you must link directly to this page only here
rather than put up your own page.
OJVRTM
Online
Journal of Veterinary Research©
Volume 18(6): 481-488, 2014.
Effect of Cuminum cyminum L. on
ovarian tissue in NMRI mice after copper sulfate administration.
Ehsanollah Sakhaee1*, Reza Kheirandish2,
Ladan Emadi3, Mohammad Reza Esmaili Nejad4, Hemad Shafiei Bafti4
1Departments of Clinical Sciences, 2Pathobiology,
3Basic Sciences, 4School of Veterinary Medicine, Shahid Bahonar University of
Kerman, Iran.
ABSTRACT
Sakhaee
E, Kheirandish R, Emadi L, Esmaili Nejad MR, Bafti HS., Effect of Cuminum cyminum L. on ovarian tissue of NMRI mice after copper
sulfate administration, Onl J Vet Res., 18(6): 481-488, 2014. Copper is an essential trace element involved
in reproduction but over-exposure can be toxic.
Groups of 10 mice each were gavaged 100mg/kg
copper sulfate (copper controls), 1 mg/kg Cuminum cyminum
essential oil (cuminum controls), copper sulfate
100mg/kg with Cuminum cyminum
essential oil 1mg/kg (treatment group), or distilled water (controls). Animals were sacrificed at 42 days. Ovarian
damage in follicles occurred in copper controls but not in water controls. Mice
given cuminum
appeared to have less toxic ovarian damage and fewer atretic
follicles with degenerative changes or apoptotic cells. The findings suggested
that Cuminum cyminum
essential oil could affect ovarian follicle damage during copper toxicosis.
Keywords: Cuminum cyminum; Copper poisoning; Histopathology;
Mice; Ovary.
FULL-TEXT (SUBSCRIPTION OR PURCHASE TITLE $25USD)