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OJVRTM
Online Journal of
Veterinary Research©
Volume 5: 26-37, 2001. Redacted
2018.
Acute toxicity of
cyanobacteria blooms from dam algae.
Andréa Nhoato MS1, Igor Vassilieff MS, PhD2, Sandra S. M. O. F. Azevedo MS, PhD 3.
1 Centro
Integrado de Ensino
Superior (CIES), Campo Mourão, PR, Brazil. Correspondence to: Andréa Nhoato;
Av. Irmãos Pereira, 270, 87300-000, Campo Mourão, Paraná, Brazil. Phone/fax: 44-523-1982; e-mail:
nhoato@yahoo.com. 2. The Center for Toxicological Assistance (CEATOX),
Institute of Biosciences, UNESP, Botucatu, SP, Brasil. 3. Núcleo de Pesquisas de Produtos
Naturais (NPPN), UFRJ, Rio de Janeiro, RJ, Brazil.
ABSTRACT
A Nhoato, I Vassilieff, Sandra SM, Azevedo
OF., Acute toxicity of cyanobacteria blooms from
dam algae. Onl
J Vet Res., 5: 26-37, 2001. Toxic blooms of cyanobacteria have been reported to cause livestock
deaths in many countries. Microcystin
concentrations of 0,58 mg/mg (May 1998 sample) and
5,02 mg/g (June 1999) were found in surface water from Jurumirim
Dam in Southern Brazil. Intraperitoneal injections in mice resulted
in an LD50 for 67- 51 (May 1998 sample) and 70, 71 mg/kg (June 1999 sample)
with death occuring between 30 minutes to 20 hours.
Dose-dependent increases in liver weight ranging from 27-71% of body weight
occurred. Livers appeared engorged with diffuse hemorrhage, congestion,
hypertrophy of hepatocytes, Küpffer cell hyperplasia
and focal microdrops esteatosis.
The samples were significantly more toxic than reported previously;
Cyanobacteria from the Jurumirim Dam represent a
potential risk to the local population and livestock.
KEY-WORDS Cyanobacteria, dam, toxicity,
mice.
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