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OJVRTM
Online
Journal of Veterinary Research©
Volume 23 (10):1007-1016,
2019.
Sutureless
amniotic membrane 2-Octyl cyanoacrylate patch for treatment of corneal alkali
burn in dogs.
Abbaszadeh M1, Aldavood SJ1, Foroutan A.R2, Azizzadeh M3 , Izadi SS1, Selk Ghaffari M4.
1Department of Clinical
Sciences, Faculty of Veterinary Medicine, University of Tehran. 2Department of Clinical Sciences, Eye Research Center, Iran
university of Medical Sciences, Tehran. 3Department of Clinical Sciences, Faculty of Veterinary
Medicine, Ferdowsi University, Mashhad. 4Department of Clinical Sciences, Faculty of Veterinary
Medicine, Islamic Azad University-Karaj Branch, Karaj, Iran. Work was
completed at internal medicine research center, Department of Clinical Sciences,
University of Tehran, Iran and was not supported by any grant.
ABSTRACT
Abbaszadeh M, Aldavood SJ,
Foroutan AR, Azizzadeh
M, Izadi SS, Selk Ghaffari
M., Sutureless amniotic membrane 2-Octyl
cyanoacrylate patch for treatment of corneal alkali burn in dogs, Onl J Vet Res., Volume 23 (10):1007-1016, 2019.
Authors
describe surgery and clinical outcomes of a tissue adhesive 2-Octyl
cyanoacrylate (Dermabond) amniotic membrane patch for
treatment of experimental corneal burn in dogs. Alkali wounds were inflicted on
the central corneas of dogs under anesthesia by applying a round filter paper,
6.0 mm diameter, soaked in 1 N NaOH for 60 sec unilaterally
on each eye. Three groups of 5 dogs each were uncovered controls (1), covered
by amniotic membrane with amniotic cell membrane sutured to
cornea with 10–0 nylon (2), or covered with amniotic membrane with 2-Octyl
cyanoacrylate (3). Operating time, clinical outcome, epithelial defects, opacity,
blepharospasm, membrane retention, vascularization
and ocular discharges were monitored 21 days. Surgery time in dogs treated with
adhesive membrane was less than those sutured (P<0.001). Membrane persisted
longer (P < 0.023) and cornea healed faster with adhesive (P = 0.038). However, we found no
differences with corneal opacity or blepharospasm. Ocular discharges were also less in dogs
treated with adhesive membrane and none of the corneas stained.
Key words: Dog, Amniotic membrane, 2-Octyl cyanoacrylate,
Dermabond, corneal alkali burn.
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