Volume 23 (6):555-567, 2019.
Effect of
erythromycin on pharmacokinetics of Amlodipine in hypertensive rabbits.
Rana M Ahmad and Orooba MS Ibrahim.
Department of
Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine,
University of Baghdad, Iraq.
ABSTRACT
Ahmad RM, Ibrahim OMS., Effect of
erythromycin on pharmacokinetics of amlodipine in hypertensive rabbits, Onl J Vet Res., 23 (6):555-567, 2019. Two groups of 6 cannulated
rabbits each, were given oral 0.21mg/kg amlodipine once
with or without 22mg/kg erythromycin every 6 hours for 24 hours. Another two groups of 6 normo and hypertensive rabbits were used as controls. Blood
was taken at 0, 1 and intervals to 144 hours for measurement of amlodipine and
erythromycin by spectrophotometry. Blood pressure was measured at intervals with cuffed Doppler ultra sound transducer.
Bioavailability of amlopidine
was higher (p < 0.05) given with erythromycin with Cmax
of 4.40 ug/ml at 9h and AUC 125 ug/ml/h
compared with 2.03 μg/ml and 96.1 μg/ml/h in rabbits given only amlopidine.
We found reduced clearance (Cl) of 57.3L/kg/h and increased distribution (Vd) 5390L/kg for amlopidine given
with erythromycin compared with those administered amlopidine
only ( Cl 74.31 L/kg/hr and AUC 3715 L/kg)
respectively. We found large reductions in blood pressure in rabbits given aminolidine with erythromycin. These results suggest that
increased biovailabilty of aminolipine
due to erythromycin might decrease blood pressure further in rabbits.
Keyword: pharmacokinetic,
amlodipine, erythromycin, Interaction, hypertension. Raw data received
FULL-TEXT (SUBSCRIBE OR PURCHASE
TITLE)