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OJVRTM
Online Journal of Veterinary Research©
(Including Medical and
Laboratory Research)
Established 1994
ISSN 1328-925X
Volume 29 (8): 477-480, 2025.
Effects of Doxorubicin on ventricular myosin, actomyosin
ATPases and creatine kinase of male Wistar rats.
Sukullaya Assarasakorn DVM
MSc, Chollada Buranakarl DVM
PhD, Prasan Dhumma-Upakorn PhD.
Faculty of Veterinary
Science, Pharmacology, Chulalongkorn University,
Bangkok, Thailand.
ABSTRACT
Assarasakorn S, Buranakarl C,
Dhumma-Upakorn P., Effects of Doxorubicin on ventricular
myosin, actomyosin ATPases
and creatine kinase of male Wistar
rats, Onl J Vet Res., 29 (8): 477-480, 2025. We
describe
subacute effect of doxorubicin on myosin
ATPase, actomyosin ATPase, and creatine
kinase of cardiac ventricles from 24 male
Wistar rats (250-300 g). Twenty four rats were
injected 2.5 mg/kg doxorubin intraperitoneally twice
and 24 controls were injected 5ml/kg saline before death on day 10 by cervical
dislocation. Isolated ventricles from both groups were excized
for cardiac enzymes at day 10. In those given doxorubin
we found 0.255 + 0.009 and controls 0,264 + 0.009 mM Pi mg-1 protein Myosin ATPase, and 0.193+0.007 and 0.181+0.011
mM Pi mg-1 protein Actomyosin
ATPase (P > 0.05). However, for creatine kinase we
found 5.33+0.21 mU L-1 in treated rats and 5.92+0.17 mU L-1 in controls being a ~10% difference (P < 0.05). Findings
suggest subacute doxorubicin may suppress creatine
kinase in ventricles of rats.
Keywords :
Actomyosin ATPfourase; Creatine kinase; Doxorubicin; Myosin ATPase; Rat,
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