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OJVRTM
Online Journal of
Veterinary Research
Volume 10 (1) : 17- 19, 2006. Redacted 2018.
Effects of Doxorubicin on isolated rat ventricles
enzyme activity
Sukullaya Assarasakorna
(DVM, MSc), Chollada
Buranakarla (DVM, PhD),
Prasan Dhumma-Upakornb (PhD).
aDepartment of Physiology, Faculty of Veterinary
Science, Chulalongkorn University, Henri Dunant Road,
Patumwan, bDepartment of Pharmacology, Faculty of
Pharmaceutical Science, Chulalongkorn University,
Henri Dunant Road, Patumwan, Bangkok, Thailand, 10330
ABSTRACT
Assarasakorn S,
Buranakarl C, Dhumma-Upakorn
P, Effects of Doxorubicin on Enzyme
Activities of Isolated Rat Ventricles, Onl J Vet Res., 10 (1) : 17-19, 2006. The subacute effects of
doxorubicin on myosin ATPase, actomyosin ATPase, and creatine kinase were
evaluated on isolated ventricles of 24 male 250-300g Wistar rats. Treated rats
were injected twice intraperitoneally with 5 mg/kg doxorubicin and controls
with intraperitoneal saline. Enzymes
from isolated ventricles were determined at 10 days after treatment. Myosin and
actomyosin ATPase in treated animals were not different from those of control
group but there was a significant reduction in creatine kinase in treated rats
(P<0.05). The findings suggest that subacute h doxorubicin did not alter
cardiac myosin and actomyosin ATPase, but might suppress creatine kinase.
Keywords : Actomyosin
ATPase; Creatine kinase; Doxorubicin; Myosin ATPase;
Rat.
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