Effect of cannulated veno-arterial and left heart bypass cooling (25Co) with autologous oxygenation on arterial blood components and gases in a sheep model.

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Online Journal of Veterinary Research©

Volume 17(8):436-443, 2013. Redacted 2017.

Effect of cannulated veno-arterial and left heart bypass cooling (25C^o) with autologous oxygenation

on arterial blood components and gases in a sheep model.

Martín A Marcos^a, Javier Mouly^a, Oscar Robledo^a, Eduardo J Durante^a, Carlos A. Presa^b.

^aCentral Department of Surgery. Veterinary Science Faculty. La Plata University. Buenos Aires and ^bPediatric Heart Surgery Department. Sor Maria Ludovica Children's Hospital. La Plata, Buenos Aires. Argentina.

ABSTRACT

Marcos MA, Mouly J, Robledo O, Durante EJ, Presa CA., Effect of veno-arterial and left heart bypass cooling (25C^o) with autologous oxygenation on arterial blood components and gases in a sheep model, Onl J Vet Res., 17(8):436-443, 2013. The effect of 25°C cooling induced by cannulated veno arterial (VAB 5 sheep) and left heart bypass (LHB 5 sheep) circulatory support on an in situ hypothermic lung function sheep model is described. The sheep were cooled without inducing cardiac inotropic effects or arrhythmia. The time for cooling from 38°C to 25°C, averaged 100 minutes in VAB and 60 minutes in LHB sheep. Mean arterial pressure declined in both groups whereas central venous pressure, heart rate, hematocrit, PaCO2, PaO2 and SaO2 did not vary significantly between VAB and LHB groups. The experiment showed that it is possible to induce cooling through VAB or LHB cannulation allowing partial but adequate perfusion of ischemic sensitive organs in sheep. PaO2 values could be improved with different ventilator modes and capnography-guided ventilation. This model could allow for the assessment of lung function in hypothermia without use of membrane oxygenators or lung protective drugs.

Key words: circulatory assistance, autologous oxygenation, moderate hypothermia, animal model.

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