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OJVRTM

Online Journal of Veterinary Research©

Volume 7 : 99-105, 2003. Redacted 2018.


Effect of eformoterol on exercise-induced pulmonary hemorrhage in training thoroughbred horses.

 

 Ladaga GJB1,2, Pont Lezica F1, Ulloa F1, de Erausquin GA1,3, Ruzzante G1, Negrelli C1 del Carril R1.

 

INCA Group1, Buenos Aires, Argentina; Laboratorio Fundación2, Buenos Aires, Argentina; and Washington University School of Medicine3, St Louis, Missouri. Address for correspondence: Gabriel A. de Erausquin, MD, PhD Washington University School of Medicine, 660 S. Euclid Ave, Campus Box 8134, St. Louis, MO 63110 e-mail: erausquing@neuro.wustl.edu

 

ABSTRACT

 

Ladaga GJB, Pont Lezica F, Ulloa F, de Erausquin GA, Ruzzante G, Negrelli C, del Carril R . Evaluation of the efficacy of eformoterol on Exercise-induced Pulmonary Hemorrhage in training thoruoughbred horses. Onl J Vet Res., 7:99-105, 2003. Exercise-induced pulmonary hemorrhage (EIPH) is a major medical problem in competitive horses, with economic effects on breeders and trainers. The pathophysiology of EIPH is poorly understood and current pharmacological treatment is inadequate. Eformoterol is a b2 adrenergic agonist with putative vascular, bronchial, and anti-inflammatory effects. A blind trial of intramuscular eformoterol in thoroughbred horses with EIPH during competitive training was performed during 180 training sessions in 29 horses (2-4 years-old, 400-500 kg). The first 90 sessions were used to classify horses with endoscopically confirmed EIPH in either light (LB) or heavy (HB) bleeders. Training sessions (speed 15.57-17.73 m/sec, 600-1800 m) performed 2 h after receiving 0.040 (LB), or 0.080 (HB) mg eformoterol; were followed by physical evaluation at 40 min and endoscopy at 60 min after completion. Following eformoterol, no epistaxis was observed in either group. Endoscopically, 95 % of LB had less than 1+ bleeding, and none had greater than 2+ hemorrhage. In HB, 85% had less than 1+ bleeding, and only one animal showed greater than 2+ hemorrhage. Performance was assessed as "optimal" by blind jockeys and trainers. Vital signs returned to baseline 40 min after the training session. The findings suggest that eformeterol given at the above doses did not induce abnormalities in training horses.

 

KEYWORDS: eformoterol, thoroughbred, exercise-induced pulmonary hemorrhage.


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