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OJBTM
Online Journal of Bioinformatics©
Volume 8 (1):61-73, 2007
In Silico identification
of antioxidant gene G6PD in Caenorhabditis elegans
Jitendra N, Prachi S, Alpana V, Shakti S
Bioinformatics Centre, AIB, Amity University, Noida, UP, INDIA
Jitendra N, Prachi S, Alpana V, Shakti S., In
silico identification of Antioxidant gene G6PD
in Caenorhabditis elegans, Online
J Bioinformatics 8 (1) : 61-73, 2007. Interest
in C. elegans as a target for drug discovery has grown considerably,
particularly in the pharmaceutical and agro-chemical industries. C. elegans
is a proven model system for investigating numerous neurodegenerative
diseases and physiological processes. Several neurodegenerative disorders have
been modeled in C. elegans
including Huntington’s disease, Alzheimer’s disease, Parkinson’s disease, and
cancer. C.elegans
models are also used for antioxidant screens, diabetes, and determining
alterations in gene expression. In humans there are 81 genes known to have
antioxidant properties with 60% similarities in the genome of Caenorhabditis elegans
with Homo sapiens, but only
five genes Prdx-2 Prdx-3, clk-2, clk-1 and gro-1, show antioxidant properties
in Caenorhabditis elegans.
These findings suggest that other unknown genes of Caenorhabditis elegans
may have antioxidant properties. A BLAST of known antioxidant gene in Homo sapiens with the genome of Caenorhabditis elegans
identified a locus in Caenorhabditis elegans contig named B0035 that showed good homology with G6PD gene
in Homo sapiens geneID 2539 present on chromosome
number X located at Xq28.
KEY WORDS: Antioxidant, Caenorhabditis elegans,
BLAST, G6PD gene, Contig