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OJVRTM
Online Journal of Veterinary Research©
Volume 20(8):514-520, 2016.
Immune markers in mice vaccinated recombinant bacteriophage m2e-ha2
epitopes of influenza virus.
Hadis
Fathizadeh1, Mehdi Golchin1, Masoud
Moghadaszadeh1,2, Hadi
Tavakkoli1, Mohammad Khalili1, Maryam Maazallahi1
1Department of
Pathobiology, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, 2Biotechnology Research Center,
Tabriz University of Medical Sciences, Tabriz, Iran.
ABSTRACT
Fathizadeh
H, Golchin M, Moghadaszadeh M, Tavakkoli
H, Khalili M, Maazallahi M.,
Immune markers in mice vaccinated recombinant bacteriophage m2e-ha2 epitopes of
influenza virus, Onl J Vet Res., 20(8):514-520, 2016. Extracellular
domains of M2 (M2e) and HA2 subunit of hemagglutinin (HA) have conserved
epitopes in human and avian influenza A viruses which could be used in
influenza A vaccines. We describe hybrid phage displaying the epitopes of
SLLTEVET and GLFGAIAGF for inducing immune protective responses against H9N2
influenza infection in BALB/c mice. The recombinant M13 phage elicited a high
immune response in mice and decreased virus shedding of virus particles in
their lungs following intranasal challenge with live H9N2 virus. A higher viral
shedding occurred in lungs of non-immunized control mice. The findings suggest
that the hybrid phage should be tested in an influenza vaccine.
Keywords: Bacteriophage
M13, M2e-HA2, Influenza, pVIII
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