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OJVRTM

Online Journal of Veterinary Research ©

(Including Medical and Laboratory Research)

Established 1994

ISSN 1328-925X

Volume 28 (2): 55-60, 2024.

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Disposition of Florfenicol in buffalo calves

Pranvendra Kumar, AH Ahmad, Anu Rahal, KP Singh.

Department of Veterinary Pharmacology and Toxicology, College of Veterinary &Animal Sciences, G.B.P.U.A.&T., Pantnagar-263145 ,India.

ABSTRACT

Kumar P, Ahmad AH, Rahal A, Singh KP, Disposition of Florfenicol in buffalo calves, Onl J Vet Res., 28 (2): 55-60, 2024., Plasma florfenicol was determined in buffalo calves following 20 mg/kg intravenous (IV) and intramuscular (IM) injections (IM). Blood (2ml) was collected in heparinized tubes by indwelling catheter in contralateral jugular vein at 0, 0.03, 0.08, 0.18, 0.25, 0.5, 1.0, 3, 6, 9 and 12 h. Plasma was extracted and analyzed for florfenicol by reverse phase high performance liquid chromatography. After IV injection, plasma florfenicol ranged 48.76 ± 2.55 by 2min to 30.1 ± 1.11μg.ml^-1 by 0.17 h and 0.85 ± 0.1 μg.ml^-1 by 12h to fit 2 two compartmental elimination (r = 0.99). By IM, peak plasma levels of 7.63±0.15 μg.ml^-1 occurred by 1h and declined to 0.42±0.05 μg.ml^-1 at 12 h to fit a 1 compartmental model. Absorption half-life (t_1/2ka) was 0.32±0.02h and elimination half-life (t_1/2ke) was 3.35±0.9h, AUC 49.58±1.3 μg.ml^-1.h,, Cl 404.22±10.72 ml.kg^-1 h^-1, and Vd_darea 1952.91±64.5 ml.kg^-1. Elimination half-lives by IV was 2.38h. and IM 2.88h. We find that 13mg/kg IV florfenbicol may treat susceptible bacterial infections but by IM injection unsuitable due to low bioavailability.

Key-words: Florfenicol, intravenous, intramuscular, cattle, disposition.