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OJVRTM
Online Journal of Veterinary
Research©
(Including Medical and Laboratory Research)
Established 1994
ISSN 1328-925X
Volume 30 (1): 32-41, 2026.
Effect
of vitamin E-ginger on fluoride-induced testicular infertility in rats.
Elbohi KM, Abd El-Rahman
SS.
Faculty
of Veterinary Medicine, Cairo University, Egypt.
ABSTRACT
Elbohi
KM, Abd
El-Rahman SS., Effect of vitamin
E and ginger on fluoride-induced testicular infertility in rats., Onl J Vet Res 30 (1): 32-41, 2026. We describe effect of vitamin E and ginger oil on sodium
fluoride (NaF) induced testicular infertility. Four groups of 5 male Sprague Dawley rats each
were gavaged 20mgNaF/kg (1), with (2) or without (3) 20mg/100g
vitamin E and 20mg/100g 20ml/kg ginger oil (4) daily for 28 days. Controls were
not treated. Compared with controls, in rats gavaged
fluoride, we found increased
testes (24%) and seminal (14%) weights but decline in epidimys (81%)
and postrate (57%) weights (P < 0.01). In those
given fluoride with Vitamin E these values were -16%, -81, 14 and -57% (P < 0.001), with ginger -16, -45, -22 and -28% (P < 0.001)
and with both, only epidymal weight declined 18% (P
< 0.01). Serum testosterone declined 44, 21 and 11% whereas testes levels
fell 49, 18 and 13%. There
was no effect in those given fluoride with Vitamin with ginger. Microscopy revealed that NaF inhibited
spermatogenesis and spermiation, induced necrosis of spermatogonia, abnormal spermatid and cellular hypertrophy
and reduced sperm count, motility and viability and increased abnormal spermatozoa (P<0.001).
Results suggest Vitamin-E with ginger oil may inhibit testicular related
infertility in rats
Key Words: fluoride toxicity, male fertility, ginger, vitamin E.
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