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OJVRTM
Online Journal of Veterinary Research©
Volume 13 (1):1-11,
2009. Editors: Extensively redacted 2017.
Effect of Vitamin E and ginger oil on
fluoride-induced testicular disorders in male Sprague-Dawley rats.
Elbohi KM*, Abd El-Rahman SS**.
* Department(s) of Forensic Medicine
&Toxicology and** Pathology, Faculty of Veterinary Medicine, Cairo
University, Egypt.
ABSTRACT
Elbohi KM, Abd El-Rahman SS., Effect of Vitamin E and ginger oil on
fluoride-induced testicular disorders in male Sprague-Dawley rats. Onl J Vet Res 13(1):1-11, 2009. We report effect of oral vitamin E and ginger oil on adverse effects of sodium fluoride (NaF) on fertility parameters in male rats. Groups of 9 rats
each were gavaged 20mg NaF/kg/day
for 28 days and given 20mg/100g/day vitamin E with or without 20ml/kg/day
ginger oil. Controls were not given anything. Fluoride induced histological
alterations in male genital organs including reduced spermatogenesis and spermiation, necrosis of spermatogonia,
abnormal spermatid forms and spermatid giant cells. Sperm count and motility
declined significantly (p<0.001) with reductions (P< 0.001) in sperm
viability and a high percent of abnormal spermatozoa. Significant decreases (P<0.001) in serum
and testicular testosterone occurred. We find that vitamin-E and ginger oil
reduced testicular disorders in rats given fluoride.
Key Words: fluoride toxicity, male fertility, ginger, vitamin E.
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