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OJVRTM
Online Journal of Veterinary
Research©
Volume 24 (4):198-210, 2020
Effect of gallic acid on
aluminum chloride induced liver toxicity and DNA fragmentation in rats.
Batool Sareem Zekair and Khalisa Khadhim Khudair.
Department of Physiology. Biochemistry. and Pharmacolology, College of
Veterinary Medicine, University of Baghdad, Iraq.
ABSTRACT
Zekair BS, Khudair KK.,
Effect of gallic acid on aluminum chloride induced
liver toxicity and DNA fragmentation in rats, Onl J
Vet Res., 24 (4):198-210, 2020. We report effect of gallic
acid on aluminum chloride induced hepatic toxicity and DNA fragmentation in
adult Wistar rats. Groups of 6 rats each were given
100mg/kg gallic acid IP, with or without 150mg/kg
oral aluminum chloride daily for 60 days. Controls were given distilled water.
Fasting blood samples were collected monthly (3) for liver function tests. At
euthanasia, liver tissue was excised for DNA fragmentation tests. Compared with
controls (P < 0.05), in rats given aluminum chloride we found elevated serum
alanine (~70-94%), aminotransferase (~44-73%), alkaline phosphatase (~22-33%)
and gama-glutamyl-transferase
(26-43%). Aluminum chloride induced liver DNA fragmentation detected by comet
assay (30-80%). In those given gallic acid with
aluminum chloride the values were 68-92%, 31-67%, 15-27%, respectively and no
change with alkaline phosphatase or DNA fragmentation.
Key Words: Gallic acid,
ALCL3, DNA fragmentation, liver
enzymes.