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OJVRTM
Online
Journal of Veterinary Research©
Volume 22 (3):
165-173, 2018.
Effect
of vitamin B6 on gentamicin-induced nephrotoxicity in Sprague-Dawley rats.
A. Derakhshanfar (Phd-DVM);
A. Bidadkosh (DVM) and M. H. Imanian (DVM).
Department of Pathology, Faculty of Veterinary
Medicine, Shahid Bahonar
University of Kerman, Kerman, Iran.
ABSTRACT
Derakhshanfar A, Bidadkosh A, Imanian MH., Effect of vitamin B6 on gentamicin-induced nephrotoxicity
in Sprague-Dawley rats, Onl J Vet Res., 22 (3): 165-173,
2018. Effect of low and high dose supplement of vitamin B6 on
gentamicin-induced nephrotoxicity in Sprague Dawley rats is described. It
has been postulated that there is a correlation between pyridoxal 5'-phosphate (PLP)
level and nephrotoxicity. Groups of 10 male Sprague-dawley rats each were injected intramuscular (IM) 80mg/kg gentamicin, 200mg/Kg
vitamin B6, and 80mg/Kg gentamicin with 100mg/kg or 200mg/kg vitamin B6 daily
for 10 days. Controls were injected 5 ml distilled water. After treatments, serum
creatinine, sodium, potassium, renal
gentamicin and PLP concentrations were determined along with microscopy
of kidneys. Compared with controls, gentamicin
increased in renal tissue whereas creatinine clearance, sodium, potassium and kidney PLP declined. 200 mg/kg vitamin B6
with gentamicin reduced renal
gentamicin concentration, increased creatinine clearance and reduced serum sodium and potassium. Microscopy
revealed minimal changes in renal
tissue of rats co-administed
B6 with gentamycin. Changes described above were significant (P < 0.05). Results
suggested that B6 at high doses may protect kidney tissue against gentamycin
toxicity in Sprague-Dawley rats.
Keywords:
Gentamicin, Nephrotoxicity, Vitamin B6, Pyridoxal 5-phosphate, Rat.
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