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OJVRTM
Online Journal
of Veterinary Research©
(Including Medical and Laboratory Research)
Established 1994
ISSN 1328-925X
Volume 28(1): 1-5, 2024.
Pharmacokinetics
of Gentamicin in buffalo calves after IV administration.
Sushma Lalita Baxla1, C. Jayachandran2, Birendra Kumar Roy3, Ravuri
Halley Gora3
Sushma Lalita Baxla1,
C.Jayachandran2, Birendra Kumar Roy3,
Ravuri Halley Gora 3Dept. of Veterinary Pharmacology & Toxicology,
College of Veterinary Science & A. H., 2Bihar Veterinary College Patna, 3Birsa
Agricultural University, Ranchi, India.
ABSTRACT
Baxla SL, Jayachandran C, Roy BK, Gora
RH., Pharmacokinetics of Gentamicin in buffalo calves after IV administration, Onl J Vet Res., 28 (1): 1-5, 2024. We report disposition kinetics of gentamicin after single intravenous
dose of 5mg/kg in 5 buffalo calves. Mean
peak plasma 19.80 ± 1.36µg/ml occurred at 0.042h still detected by 24h with a
mean levels of 0.023 ± 0.03µg/ml. Mean therapeutic gentamicin (≥ 2 µg/ml)
was maintained 6h in plasma whereas in urine 48h with a mean peak of 83.42 ±
3.17 µg/ml at 1.5h and a mean therapeutic concentration ≥ 2 µg/ml for 24h.
Distribution rate constant was 1.058 ± 0.100 h-1 and distribution half
life 0.69 ± 0.08h suggesting rapid distribution. The elimination rate
constant of 0.139 ± 0.008h-1 and elimination half-life of 5.05 ±
0.30h suggested slow elimination at 0.351 ± 0.023h-1 with a total
body clearance of 1.86 ± 0.16ml/kg/min from the central compartment. High mean
residential time of 5.79 ± 0.34h suggested that gentamycin levels remained for
a longer period in buffalo calves compared with other animals. The high Vdarea of 0.80 ± 0.04L/kg was supported by a tissue
to plasma concentration of 1.54 ± 0.16.
Key
words: Pharmacokinetics, gentamicin, buffalo calves, intravenous.