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OJVRTM
Online Journal of Veterinary Research©
Volume 23 (5):414-424, 2019
Effects of chronic oral monosodium
glutamate on body weight and liver histology in Wistar
rats.
Ali A Tala'a2 and Amer M Hussin1
1Belad Al-Rafidain
University College, Diyala, 2College of Veterinary
Medicine, University of Fallujah, Iraq.
ABSTRACT
Tala'a AA, Hussin
AM., Effects of chronic oral monosodium
glutamate on body weight and liver histology in Wistar
rats, Onl J Vet Res., 23
(5):414-424, 2019. Groups of 8
mature Wistar male rats were given daily 15mg oral
monosodium glutamate (MSG) 30 or 75 days. Eight controls were given water. Rats were sacrificed
at days 30 and 75 for liver tissue, microscopy, cytology and mitotic index, and
blood for serum AST and ALT. Compared
with controls, body weights increased ~28-37% and liver weights ~8-14% (p <
0.05). Hepatocytes were 24-26% more numerous and hyperplastic (11-19%), nuclei
41-44%, and binucleated cells 55-62% more frequent in
rats given GMS. Apoptotic and Kupffer cells increased
37-57% and serum AST 47% and ALT 60% Our findings suggest that chronic
intake of high doses of GMS may affect rat livers.
Keywords: Chronic MSG, liver, rat, weight. Raw data provided after Reference list.
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