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OJVRTM
Online Journal of Veterinary Research©
Volume 24(7): 420-427,
2020.
Effect of gold chloride trihydrate on serum liver enzymes and liver histology in male
versus female rabbits.
Mustafa Fadhil1, Bahaa Fakhri Hussein1,
Muhammed Mizher Radhi2
1College of
Veterinary Medicine, University of Baghdad, 2Radiology Dept., Health
and Medical Technology College-Baghdad, Middle Technology University (UTM),
Iraq.
ABSTRACT
Fadhil M, Hussein
BF, Radhi MM., Effect of gold chloride trihydrate on serum
liver enzymes and liver histology in male versus female rabbits, Onl J Vet Res., 24(7): 420-427, 2020. Gold derivatives
are used to treat rheumatoid arthritis and cancer. Authors
describe changes in serum liver enzymes and histopathology in male and female
rabbits injected 2, 3 and 4mg/kg gold chloride subcutaneously daily for 45 or
90 days. Blood was taken and rabbits sacrificed at 45 and 90 days. Compared
with controls we found large increases (~57%) in mean serum alkaline
phosphatase by 90 days in both sexes. Gold chloride at any dose induced severe
anemia in female rabbits with red cells declining ~59-96% (P < 0.001). Platelets
increased in both and hemoglobin remained within normal limits. By 45 days
treatment, we found large increases in white blood cells (~45-71%) and
lymphocytes (~71%) in female rabbits but not in males. In males these values
only increased by 90 days and with higher doses. Compared with untreated
controls we observed pathological changes in hepatocytes, portal triads and
sinusoids including anisokaryosis, nuclear vesiculation, binucleation,
cytoplasmic inclusions, cytoplasmic swelling, hydropic degeneration and
necrosis. Our hematology/sera results suggest that gold chloride may be more
toxic in female rabbits.
KEY WORDS:
Gold chloride, rabbits, serum liver, enzymes, hepatotoxicity, histology.
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