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OJVRTM
Online
Journal of Veterinary Research©
Volume 23 (6):522-543, 2019.
Effect of Green tea (Camellia sinensis)
on acrylamide induced
cardiac toxicity in adult Wistar rats.
Hind Abood Mahdi and Baraa Najim
Al-Okialy
Department of Physiology, Biochemistry
and Pharmacology, College of Veterinary Medicine /University of Baghdad, Iraq.
ABSTRACT
Mahdi HA, Al-Okialy
BN., Effect of Green tea (Camellia sinensis) on
acrylamide induced cardiac toxicity in adult Wistar
rats, Onl J Vet Res., 23 (6):522-543,
2019. We report effect
of oral alcoholic extract of green tea Camellia sinensis
on cardiac toxicity
induced by acrylamide (ACR) in rats. Four groups of 5 female Wister rats each were intubated 1mg/kg acrylamide
(1) with (2) or without (3) 200mg/kg alcoholic extract of green tea (GT) daily
for 35 days. Controls were intubated distilled water (4). Fasting cardiac puncture blood samples were collected at 0, 21 and
35 days under anesthesia for serum catalase, peroxy-nitrite radicals and troponin–I (cTn-I). Cardiac tissue was excised for malondialdehyde (MDA), reduced glutathione (GSH) and blood
for DNA fragmentation. In rats given
ACR alone, we detected decreased catalase and GSH but increased cTn-I, peroxynitrite
radicals and MDA in cardiac tissue In those given ACR we found MDA with DNA
damage in leukocytes compared with other treatments. In rats given
ACR by comet assay we found increased DNA fragmentation, comet length, head
diameter, tail length (D), DNA% in tail (E) and tail moment (F). In rats given
green tea extract with or without ACR results were similar to water controls.
Phenols in green tea may ameliorate
oxidant/antioxidant status of cardiac tissue in rats exposed to ACR.
Key-Words : acrylamide , green tea, cardiac
tissue, DNA fragment, raw data provided
after references.