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OJVRTM

Online Journal of Veterinary Research ©

Volume 15 (2): 162-167, 2011

Effect of levothyroxine on serum biochemistry and liver in chicks.

Emadi Ladan ^1* (DVM, PhD), Kheirandish Reza ²(DVM, PhD), Amiri Narjes (DVM)

¹Basic Sciences, ²Pathobiology Departments, Shahid Bahonar University, Kerman, Iran

ABSTRACT

Ladan E, Reza K, Narjes A., Effect of levothyroxine on serum enzymes and liver in chicks., Onl J Vet Res, 15 (2): 162-167, 2011. The effect of oral levothyroxine on serum biochemistry and liver histology was evaluated in Ross broiler chicks. Two groups of 12 chicks each were given daily oral levothyroxine sodium 250 (12) or 500 μg/Kg at 14 days age for 25 days to induce hyperthyroidism. Compared with non-treated controls (12) values, increased levothyroxine correlated with decreased triglyceride and cholesterol but increased ALT and AST. Basophilic cytoplasm and euchromatin nuclei were observed in hepatocytes of treated chicks, but irregular arrangement of hepatocytes and hepatic centrilobular necrosis was more evident in chicks given 500 ug/kg levothyroxine. Lymphopoiesis in hepatic parenchyma and vascular smooth muscle hypertrophy were observed in treated birds. The findings suggest that 250 ug/kg or more levothyroxin may induce hepatotoxicity in chicks.

Key Words: Hyperthyroidism, Hepatic function, Chicks

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